Stahl's Illustrated Mood Stabilizers by Stephen M. Stahl

Author:Stephen M. Stahl
Language: eng
Format: mobi
ISBN: 9780521758499
Publisher: Cambridge University Press
Published: 2009-04-12T21:00:00+00:00

Chapter 5

Atypical Antipsychotics as Mood Stabilizers for Bipolar Disorder

This chapter describes the growing use of atypical antipsychotics as mood stabilizers for bipolar disorder. Some of these agents are FDA-approved for bipolar depression, mania, or maintenance treatment. Others have hypothetical efficacy in the treatment of bipolar disorder but are less well studied. The broad therapeutic effects of these agents as mood stabilizers likely derive from their similarly broad spectrum of pharmacologic actions. This chapter presents the fourth step in the symptom-based treatment algorithm, namely, an in-depth presentation of pharmacologic mechanisms of eight different mood stabilizers from the atypical antipsychotic drug class. As in Chapter 4, drug introductions are followed by particular mechanisms of action hypothesized to contribute to each drug’s potential efficacy. The various atypical antipsychotics are discussed in terms of the present understanding of each agent’s mechanism and function. This chapter continues to build on neurobiology presented in Chapter 3 to describe the dopamine agonist spectrum and its potential role in treating the symptoms of bipolar disorder.

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